RARE CASE OF INFLAMMATORY PSEUDOTUMOUR OF CENTRAL NERVOUS SYSTEM


Inflammatory Pseudotumours(IPT) are mostly benign lesions , mimicking malignant lesions and affecting almost all organ systems and are characterised by fibrotic ground tissue and polyclonal mononuclear infiltrate on histopathology. It is a disease of unknown pathogenesis and the brain is a rare site of occurrence. Here we present one such case we operated recently in our department.

Inflammatory Pseudotumour(IPT) is a rare nonneoplastic condition that usually involves the lung and orbit, but is known to affect almost all the organ systems. The term ´Inflammatory Pseudotumour´ was coined by Umiker and Iverson in 1954, after finding out that the clinical and image findings mimicked that of a malignant lesion. The cause of IPT is unknown. It is characterised histologically by the presence of acute and chronic inflammatory cells with a variable fibrotic response. It is also called spindle cell Pseudotumor, plasma cell granuloma, inflammatory myofibroblastic tumor. The condition is rare in the brain and is usually an intracranial extension of an extracranial tumour arising from the orbit. Rarely , the condition is primarily intracranial or within spinal cord, affecting young men mostly.

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